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Molecular Weight
Purity
Storage
Appearance
Solubility
01
Chonluten is a synthetic tripeptide, Glu-Asp-Gly (EDG). It is one of the short-peptide bioregulators developed by the Khavinson group at the St Petersburg Institute of Bioregulation and Gerontology, where it was studied in relation to the respiratory tract, alongside the tetrapeptide Bronchogen.
The same chemical structure is registered under CAS 75007-24-8 and is also indexed as “T-34 tripeptide”, a name from an unrelated 1980 study. Published work on Chonluten comes mainly from the Khavinson research network, with limited independent replication. It is supplied as a lyophilized reference material for in vitro and analytical research only.
02
Chonluten is one of the smallest and most acidic peptides in this catalogue.
Sequence
Glu-Asp-Gly, with a free N-terminal amine and a free C-terminal acid.
Charge
The glutamate and aspartate side chains plus the C-terminus give three negative charges at neutral pH, against one positive charge at the N-terminus, so the net charge is about −2. It is extremely polar and water-soluble.
Asp-Gly bond
An aspartate followed by glycine is the sequence most prone to aspartimide (succinimide) formation, leading to isoaspartate and occasional backbone cleavage. This is Chonluten’s main chemical weak point.
Family pattern
Chonluten shares the Glu-Asp start of Pinealon (Glu-Asp-Arg), Crystagen (Glu-Asp-Pro) and Ovagen (Glu-Asp-Leu), differing only in the last residue.
Naming note
A few suppliers list Chonluten as Gln-Asp-Gly, which is a different molecule about 1 Da lighter. The literature and registry sequence is Glu-Asp-Gly, so confirm it on the certificate of analysis.
03
Published research on Chonluten is limited and comes mainly from one research network.
Respiratory tissue models
Studies in cultured bronchial epithelial cells and lung tissue preparations have reported changes in stress-response and inflammation-related gene expression, such as heat-shock proteins and inflammatory mediators.
Gene expression hypothesis
The research group proposes that short peptides of this kind act on gene expression in a tissue-specific way. This is the group’s own framework and has not been widely confirmed independently.
These findings are cited as research context only; no effects are claimed for this material.
04
Bioregulator comparisons
A reference compound alongside Bronchogen and other short peptides of the series in respiratory-tissue models.
Asp-Gly chemistry
A clean, minimal model for studying aspartimide and isoaspartate formation at an Asp-Gly bond.
Small-peptide analytics
A very polar, low-mass peptide for testing HPLC retention of hydrophilic analytes and LC-MS at low m/z.
05
Storage
Store the lyophilized powder at −20 °C, sealed and desiccated.
Asp-Gly reactions
Isoaspartate formation at the Asp-Gly bond is fastest in the mildly acidic range (around pH 4–6) and at higher temperatures, while strongly acidic conditions favour backbone cleavage. Keep solutions cold, near neutral pH, and use them promptly.
Reconstitution
Highly soluble in water and aqueous buffers.
Solutions
Freeze single-use aliquots and avoid repeated freeze–thaw cycles.
Other pathways
There is no aromatic residue, cysteine or methionine, so oxidation is not a concern. The N-terminal glutamate can slowly cyclise to pyroglutamate.
06
Chonluten needs methods suited to very small, polar peptides.
HPLC
It is barely retained on standard reversed-phase C18; start at very low organic content, or use an aqueous-compatible C18 or HILIC column. Detect at about 205–214 nm, since there are no aromatic residues.
Mass spectrometry
Positive-mode ESI gives [M+H]⁺ at m/z 320.1 (monoisotopic 319.10 Da). Negative mode also works well because of its acidic residues.
Isoaspartate
IsoAsp forms have the same mass as the parent and often appear as small neighbouring peaks, so HPLC methods should be optimised to resolve them.
Impurity profile
Typical checks include isoAsp variants, the succinimide intermediate (−18 Da), pyroglutamate (−18 Da), Asp-Gly cleavage products and counter-ion content.
07
It is the one-letter code for Chonluten’s sequence: E for glutamic acid, D for aspartic acid and G for glycine, i.e. Glu-Asp-Gly.
Both come from the same research group and were studied in relation to the respiratory tract. They are different peptides: Chonluten is the tripeptide Glu-Asp-Gly, while Bronchogen is a tetrapeptide containing alanine, aspartate, glutamate and leucine.
Chemically, yes. Both names refer to Glu-Asp-Gly, registered under CAS 75007-24-8. “T-34 tripeptide” comes from an unrelated 1980 study that identified the same tripeptide, while “Chonluten” is the name used by the Khavinson group.
Aspartimide formation at the Asp-Gly bond, leading to isoaspartate variants and occasional cleavage. It is fastest in the mildly acidic range (around pH 4–6) and at higher temperatures; near-neutral pH and cold storage minimise it.
Around 205–214 nm. It has no aromatic residues, so 280 nm gives no useful signal.
No. It is supplied strictly as a reference compound for laboratory and analytical research and is not for human or animal use.
Chonluten Research Reference. (2026). Pure Peptides Labs Research Catalogue. Retrieved from https://purepeptideslabs.net/research-catalogue/cellular-bioregulator-reference-compounds/chonluten/
Materials listed on this platform are supported by independent testing and published documentation for laboratory research contexts.
