Cellular Bioregulator Reference Compounds

Cellular bioregulators are short synthetic peptides (di-, tri-, and tetrapeptides) developed by the V.Kh. Khavinson group at the St. Petersburg Institute of Bioregulation & Gerontology. Each is reported to target a specific tissue type — pineal, thymic, cortical, cardiac, bronchopulmonary, vascular, hepatic, pancreatic, prostatic, cartilage, or immune — and is supplied as a lyophilized reference compound for in-vitro and analytical research only.

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Materials Referenced

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Research Sections

Overview

Research Context

Within the Khavinson-group framework, these peptides are proposed to act at the gene-expression level via direct peptide-DNA or peptide-histone interactions, modulating tissue-specific transcription factors. Published preclinical literature reports activity in oxidative-stress, immune-cell modulation, cardiomyocyte-proliferation, and DNA-thermostability endpoints. All published mechanistic work to date originates from the Khavinson group or affiliated Russian laboratories; independent Western replication is limited.

Analytical Notes

Most bioregulators contain only aliphatic and acidic / basic side chains, so 214 nm peptide-bond UV detection is required for HPLC analysis (no aromatic chromophores). Thymogen is the exception — its tryptophan residue provides 280 nm absorbance and intrinsic fluorescence. All members are highly water-soluble and reach low organic composition on reversed-phase C18 chromatography.

Materials in This Category

Research materials within this category that may be available for laboratory use

Research Reference Chonluten Short-peptide bioregulator tripeptide Glu-Asp-Gly (EDG) · Respiratory-epithelium models & Asp-Gly chemistry MW319.3 g/molPurity≥98% (HPLC)CAS75007-24-8 View reference

Research Reference Bronchogen Short-peptide bioregulator tetrapeptide Ala-Asp-Glu-Leu (ADEL) · Peptide–DNA interaction and small-peptide analysis MW446.5 g/molPurity≥98% (HPLC)CASNot assigned View reference

Research Reference Cortagen Short-peptide bioregulator tetrapeptide Ala-Glu-Asp-Pro (AEDP) · Gene-expression models & Asp-Pro chemistry MW430.4 g/molPurity≥98% (HPLC)CASNot assigned View reference

Research Reference Cardiogen Short-peptide bioregulator tetrapeptide Ala-Glu-Asp-Arg (AEDR) · Organotypic cardiac-culture models & small-peptide analysis MW489.5 g/molPurity≥98% (HPLC)CASNot assigned View reference

Research Reference Crystagen Short-peptide bioregulator tripeptide Glu-Asp-Pro (EDP) · Immune-cell gene-expression models & Asp-Pro chemistry MW359.3 g/molPurity≥98% (HPLC)CASNot assigned View reference

Research Reference Thymogen Dipeptide bioregulator L-Glu-L-Trp (oglufanide) · Immunopeptide research & tryptophan-dipeptide analysis MW333.3 g/molPurity≥98% (HPLC)CAS38101-59-6 View reference

Research Reference Pinealon Short-peptide bioregulator tripeptide Glu-Asp-Arg (EDR) · Cellular oxidative-stress models & small-peptide analysis MW418.4 g/molPurity≥98% (HPLC)CAS175175-23-2 View reference

Available for Research

Materials listed on this platform are supported by independent testing and published documentation for laboratory research contexts.

View Available Research Materials