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Molecular Weight
Purity
Storage
Appearance
Solubility
01
Cardiogen is a synthetic tetrapeptide, Ala-Glu-Asp-Arg (AEDR). It is one of the short-peptide bioregulators developed by the Khavinson group at the St Petersburg Institute of Bioregulation and Gerontology, where it was studied in relation to heart tissue.
Its sequence is Pinealon (Glu-Asp-Arg) with an extra alanine at the N-terminus, and it shares the central Glu-Asp motif seen in several peptides of this series. Published work, mainly from this research network, has examined it in organotypic heart-tissue cultures. No CAS registry number has been assigned. It is supplied as a lyophilized reference material for in vitro and analytical research only.
02
Cardiogen is a small, charged tetrapeptide.
Sequence
Ala-Glu-Asp-Arg, with a free N-terminal amine and a free C-terminal acid.
Charge
Two acidic side chains and the C-terminus give three negative charges at neutral pH; arginine and the N-terminus give two positive charges. The net charge is about −1, and the molecule is very water-soluble.
Family pattern
Several peptides in this series share a central Glu-Asp pair with different end residues: Pinealon (Glu-Asp-Arg), Crystagen (Glu-Asp-Pro), Cortagen (Ala-Glu-Asp-Pro), Bronchogen (Ala-Asp-Glu-Leu, also reported as Ala-Glu-Asp-Leu) and Epitalon (Ala-Glu-Asp-Gly).
No sensitive side chains
There is no aromatic residue, cysteine or methionine. The Glu-Asp and Asp-Arg region is the main site of chemical change.
03
Published research on Cardiogen is limited and comes mainly from one research network.
Organotypic heart cultures
A 2009 study reported that very low concentrations of Cardiogen stimulated cell proliferation in organotypic heart-tissue cultures from rats, with stronger effects in cultures from older animals.
Gene expression hypothesis
The research group proposes that short peptides such as Cardiogen interact with DNA or histones and influence gene expression. This is the group’s own framework and has not been widely confirmed independently.
These findings are cited as research context only; no effects are claimed for this material.
04
Bioregulator comparisons
A reference compound in studies comparing short peptides of the Khavinson series, particularly those sharing the Glu-Asp core.
Tissue-culture studies
Used as a test compound in organotypic and cardiomyocyte culture experiments.
Small-peptide analytics
A polar, low-mass peptide for testing HPLC retention of hydrophilic analytes and LC-MS at low m/z.
05
Storage
Store the lyophilized powder at −20 °C, sealed and desiccated.
Reconstitution
Highly soluble in water and aqueous buffers.
Chemical stability
The aspartate is the main weak point: Asp-containing bonds are relatively acid-labile, and isoaspartate formation is fastest in the mildly acidic range (around pH 4–6) and at higher temperatures. Keep solutions near neutral pH, cold and fresh.
Solutions
Freeze single-use aliquots and avoid repeated freeze–thaw cycles.
06
Cardiogen needs methods suited to small, polar peptides.
HPLC
Retained only weakly on reversed-phase C18; start at very low organic content, or use an aqueous-compatible C18 or HILIC column. Detect at about 205–214 nm, since there are no aromatic residues.
Mass spectrometry
Positive-mode ESI gives [M+H]⁺ at m/z 490.2 (monoisotopic 489.22 Da). MS/MS shows arginine-related ions, including the immonium ion at m/z 129.1.
Impurity profile
Typical checks include isoAsp variants (same mass, different retention), truncated sequences such as Glu-Asp-Arg (Pinealon, −71 Da) and counter-ion content.
07
It is the one-letter code for Cardiogen’s sequence: A for alanine, E for glutamic acid, D for aspartic acid and R for arginine, i.e. Ala-Glu-Asp-Arg.
Cardiogen is Pinealon (Glu-Asp-Arg) with an alanine added at the N-terminus. Both come from the same research group’s series of short peptides.
No CAS registry number has been assigned. It is identified by its sequence, formula (C₁₈H₃₁N₇O₉) and mass.
Around 205–214 nm. It has no aromatic residues, so 280 nm gives no useful signal.
Limited: most studies come from one research network, with little independent replication.
No. It is supplied strictly as a reference compound for laboratory and analytical research and is not for human or animal use.
Cardiogen Research Reference. (2026). Pure Peptides Labs Research Catalogue. Retrieved from https://purepeptideslabs.net/research-catalogue/cellular-bioregulator-reference-compounds/cardiogen/
Materials listed on this platform are supported by independent testing and published documentation for laboratory research contexts.
