Cellular Bioregulator Reference Compounds

Cellular bioregulators are short synthetic peptides (di-, tri-, and tetrapeptides) developed by the V.Kh. Khavinson group at the St. Petersburg Institute of Bioregulation & Gerontology. Each is reported to target a specific tissue type — pineal, thymic, cortical, cardiac, bronchopulmonary, vascular, hepatic, pancreatic, prostatic, cartilage, or immune — and is supplied as a lyophilized reference compound for in-vitro and analytical research only.

Materials Referenced

2

Research Sections

Overview

Research Context

Within the Khavinson-group framework, these peptides are proposed to act at the gene-expression level via direct peptide-DNA or peptide-histone interactions, modulating tissue-specific transcription factors. Published preclinical literature reports activity in oxidative-stress, immune-cell modulation, cardiomyocyte-proliferation, and DNA-thermostability endpoints. All published mechanistic work to date originates from the Khavinson group or affiliated Russian laboratories; independent Western replication is limited.

Analytical Notes

Most bioregulators contain only aliphatic and acidic / basic side chains, so 214 nm peptide-bond UV detection is required for HPLC analysis (no aromatic chromophores). Thymogen is the exception — its tryptophan residue provides 280 nm absorbance and intrinsic fluorescence. All members are highly water-soluble and reach low organic composition on reversed-phase C18 chromatography.

Materials in This Category

Research materials within this category that may be available for laboratory use

Available for Research

Materials listed on this platform are supported by independent testing and published documentation for laboratory research contexts.

View Available Research Materials